| Rank | Name | Pos | Location | Stars | Ht | Wt | School |
|---|---|---|---|---|---|---|---|
| #1 | Channing Ward | DE | Aberdeen, MSAberdeen Ward had more than 20 sacks for a squad that surrendered 14 points per game and went deep into the playoffs. | 4 stars | 6'4" | 250 | Mississippi |
| #2 | Anthony Alford | QB | Petal, MSPetal Alford accounted for more than 3,500 yards of total offense with 1,000-plus in both passing and rushing. | 4 stars | 6'1" | 205 | Southern Miss |
| #3 | Quay Evans | DT | Morton, MSMorton Evans recorded 72 tackles, 4.5 sacks and two fumble recoveries in 2011. | 4 stars | 6'3" | 295 | Mississippi St. |
| #4 | Richie Brown | LB | Long Beach, MSLong Beach Brown recorded more than 200 tackles during senior campaign. | 4 stars | 6'2" | 223 | Mississippi St. |
| #5 | Issac Gross | DT | Batesville, MSSouth Panola Gross competed in the Alabama-Mississippi All-Star Classic. | 3 stars | 6'3" | 270 | Mississippi |
| #6 | A.J. Jefferson | DE | Summit, MSNorth Pike Jefferson recorded 110 tackles and 12 sacks in 2011. | 3 stars | 6'4" | 240 | Mississippi St. |
| #7 | Jeremy Liggins | QB | Oxford, MSLafayette Liggins accounted for more than 2,500 yards as a senior. | 3 stars | 6'3" | 270 | LSU |
| #8 | D'Arthur Cowan | WR | Olive Branch, MSOlive Branch Cowan produced 63 receptions for 1,255 yards for state championship team. | 3 stars | 6'3" | 175 | Arkansas |
| #9 | Nick James | DT | Long Beach, MSLong Beach In 2011, James produced 62 total tackles with 31 solo stops. | 3 stars | 6'4" | 335 | Mississippi St. |
| #10 | Cedric Jiles | DB | Clinton, MSClinton Jiles recorded 37 total tackles and an interception this season. | 3 stars | 6'0" | 180 | Mississippi St. |
| #11 | Devon Desper | OL | Madison, MSMadison Central Desper was selected to play in the Under Armour All-American Game. | 3 stars | 6'4" | 295 | Mississippi St. |
| #12 | Temario Strong | DE | Batesville, MSSouth Panola Strong competed in the Alabama-Mississippi All-Star Classic. | 3 stars | 6'2" | 210 | Mississippi |
| #13 | Deonte Evans | ATH | McComb, MSMcComb Evans rushed for nearly 1,000 yards and recorded 58 tackles. | 3 stars | 5'11" | 198 | Mississippi St. |
| #14 | Xavier Grindle | RB | Columbia, MSEast Marion Grindle ran for 2,103 yards and averaged 8.76 yards per carry. | 3 stars | 5'10" | 190 | Mississippi St. |
| #15 | Adarrius Perkins | ATH | Brooklyn, MSForrest County Perkins had an interception in the Alabama-Mississippi All-Star Classic. | 3 stars | 6'2" | 185 | Mississippi St. |
| #16 | Jaborian McKenzie | ATH | Natchez, MSTrinity Episcopal McKenzie produced 100 touchdowns and more than 10,000 all-purpose yards in his career. | 3 stars | 5'8" | 169 | Vanderbilt |
| #17 | Lelland Ducksworth | LB | Hattiesburg, MSNorth Forest Ducksworth recorded 61 tackles and an interception in 2011. | 3 stars | 6'1" | 215 | Southern Miss |
| #18 | Cordarrly Gaines | OL | Jackson, MSProvine Gaines anchored offensive line and registered 19 pancake blocks. | 3 stars | 6'5" | 320 | list |
| #19 | Todd Mays | QB | Olive Branch, MSOlive Branch Mays quarterbacked Olive Branch to the state championship. | 3 stars | 6'1" | 190 | Arkansas St. |
| #20 | Adairius Barnes | ATH | Port Gibson, MSPort Gibson Barnes was selected to play in the Alabama-Mississippi All-Star Classic. | 3 stars | 5'11" | 180 | Louisiana Tech |
| #21 | D.J. Thompson | WR | Pearl, MSPearl Thompson hauled in 59 passes for 773 yards during senior campaign. | 3 stars | 6'4" | 190 | Southern Miss |
| #22 | Michael Gordon | RB | Camden, MSVelma Jackson Gordon rushed for 1,759 yards and 21 touchdowns on only 156 carries. | 3 stars | 5'10" | 185 | Arkansas St. |
| #23 | Nelson Adams | DE | Brandon, MSBrandon Adams produced 106 tackles with eight sacks in 2011. | 3 stars | 6'5" | 260 | Mississippi St. |
| #24 | Travon Travis | WR | Gulfport, MSGulfport Travis caught 26 passes as a senior. | 3 stars | 5'11" | 170 | list |
| #25 | Frederick Brown | WR | Jackson, MSJim Hill Brown was among the top receiving targets in the Jackson area. | 3 stars | 6'1" | 166 | Mississippi St. |