| Rank | Name | Pos | Location | Stars | Ht | Wt | School |
|---|---|---|---|---|---|---|---|
| #1 | Shaq Roland | WR | Lexington, SCLexington Roland finished with 79 receptions for 1,546 yards, 306 rushing yards and 33 total touchdowns during his senior season. | 4 stars | 6'1" | 170 | South Carolina |
| #2 | Quinshad Davis | WR | Gaffney, SCGaffney Davis finished with astounding 2,009 receiving yards in 2011. | 4 stars | 6'3" | 180 | North Carolina |
| #3 | Shaq Lawson | DE | Central, SCD. W. Daniel Lawson was defensive MVP of the state’s North-South All-Star game. | 4 stars | 6'3" | 240 | Clemson |
| #4 | Javarius Leamon | OL | Woodruff, SCWoodruff Leamon was a two-way line standout for state runnerup squad and competed in the Offense-Defense All-American Bowl. | 4 stars | 6'6" | 295 | S. Carolina St. |
| #5 | Ronald Geohaghan | DB | Fairfax, SCAllendale Fairfax Geohaghan recorded 112 tackles, 21 tackles for loss, 10 pass breakups and six sacks. | 4 stars | 6'0" | 185 | Clemson |
| #6 | Kwinton Smith | WR | Dillon, SCDillon Smith will play in the Offense-Defense All-America Game. | 3 stars | 6'4" | 206 | South Carolina |
| #7 | Tyler Knox | DE | Myrtle Beach, SCMyrtle Beach Knox was standout defender on team that allowed only 12 points per game. | 3 stars | 6'4" | 225 | N.C. State |
| #8 | Martin Aiken | DE | Bamberg, SCBamberg-Ehrhardt Aiken is a defensive leader for squad that produced four shutouts and reached third round of the playoffs. | 3 stars | 6'3" | 245 | Clemson |
| #9 | Jabril Solomon | DB | Hemingway, SCHemingway Soloman recorded 48 tackles and three interceptions in 2011. | 3 stars | 6'2" | 178 | East Carolina |
| #10 | Cordrea Tankersley | DB | Aiken, SCSilver Bluff Playing QB, Tankersley accounted for more than 1,500 yards. | 3 stars | 6'0" | 190 | Clemson |
| #11 | Chris Brown | WR | Hanahan, SCHanahan Brown had double-digit TD receptions despite missing half the season with a collarbone injury. | 3 stars | 6'2" | 185 | Notre Dame |
| #12 | Justin Meredith | TE | Anderson, SCT. L. Hanna Meredith was selected to play in the Shrine Bowl of the Carolinas. | 3 stars | 6'5" | 210 | Tennessee |
| #13 | Devontre Parnell | DB | Winnsboro, SCFairfield Central Parnell missed senior season after suffering an ACL injury. | 3 stars | 5'11" | 163 | Louisville |
| #14 | Gimel President | DE | Mt. Pleasant, SCWando President had a team-high 75 tackles, 24 tackles for loss and five sacks. | 3 stars | 6'3" | 240 | Auburn |
| #15 | Caleb Rowe | QB | Greer, SCBlue Ridge Rowe passed for 2,538 yards and 33 touchdowns in 2011. | 3 stars | 6'3" | 211 | Maryland |
| #16 | Marty Williams | ATH | North Augusta, SCFox Creek School Williams produced more than 3,000 rushing yards the past two seasons. | 3 stars | 6'1" | 200 | Clemson |
| #17 | Oliver Jones | OL | Ninety Six, SCNinety Six Jones anchored offensive line on team that scored 30 points per game. | 3 stars | 6'6" | 322 | Clemson |
| #18 | Jonathan McLaughlin | OL | Mauldin, SCMauldin McLaughlin helped lead offense that averaged 30 points a game. | 3 stars | 6'4" | 288 | East Carolina |
| #19 | Josh Brown | DT | Aiken, SCSouth Aiken Brown was among team leaders in tackles, tackles for loss and sacks. | 3 stars | 6'5" | 270 | Clemson |
| #20 | Kendric Salley | RB | Williston, SCWilliston Elko Rushed for more than 1,000 yards during senior campaign. | 3 stars | 5'10" | 210 | South Carolina |
| #21 | David Deleon | DT | Bamberg, SCBamberg-Ehrhardt Selected to play in Shrine Bowl of the Carolinas. | 3 stars | 6'0" | 270 | Miami (OH) |
| #22 | Casey Gladney | WR | Columbia, SCColumbia Gladney caught 63 passes for 1,291 yards and 19 touchsowns. | 3 stars | 6'1" | 177 | Texas Tech |
| #23 | Wesley Scott | DE | Ridgeland, SCRidgeland High School Scott was chosen to play in the Shrine Bowl of the Carolinas. | 3 stars | 6'3" | 245 | Miami (OH) |
| #24 | Mark Irick | WR | St. Matthews, SCCalhoun County Irick was top offensive playmaker for state playoff squad. | 3 stars | 6'3" | 185 | Virginia Tech |
| #25 | Eddie Gordon | OL | Boiling Springs, SCBoiling Springs Gordon was picked to play in the state’s North-South All-Star game. | 3 stars | 6'1" | 322 | N.C. State |
| #26 | T.J. Burrell | LB | Goose Creek, SCGoose Creek Burrell was named to the All-Region squad. | 3 stars | 5'11" | 197 | Clemson |
| #27 | Jay Jay McCullough | ATH | Fort Mill, SCNation Ford McCullough accounted for more than 600 yards of offense. | 3 stars | 6'5" | 232 | Clemson |
| #28 | Patrick Destefano | OL | Roebuck, SCDorman Destefano anchored offensive line for team that scored 30-plus points per game. | 3 stars | 6'4" | 275 | Clemson |
| #29 | T.J. Jones | OL | Myrtle Beach, SCMyrtle Beach Jones was anchor for line on one of the region’s highest-scoring teams. | 2 stars | 6'5" | 276 | Kentucky |
| #30 | Rokeem Williams | WR | Williston, SCWilliston Elko Williams competed in the state’s North-South All-Star game. | 2 stars | 6'2" | 190 | Miami (OH) |